ACTIVIN A TARGETS EXTRASYNAPTIC NMDA RECEPTORS TO AMELIORATE NEURONAL AND BEHAVIORAL DEFICITS IN A MOUSE MODEL OF HUNTINGTON DISEASE

Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Therefore, we examined th

read more

Changes in SeMSC, Glucosinolates and Sulforaphane Levels, and in Proteome Profile in Broccoli (Brassica oleracea var. Italica) Fertilized with Sodium Selenate

The aim of this work was to analyze the effect of sodium selenate fortification on the content of selenomethyl selenocysteine (SeMSC), total glucosinolates and sulforaphane, as well as the changes in protein profile of the inflorescences of broccoli (Brassica oleracea var.Italica).Two experimental groups were considered: plants treated with 100 mmo

read more



Current problems of combating environmental crime in Ukraine

The publication is dedicated to the scientific analysis of the problems of identifying and qualifying criminal offenses against the environment in order to develop appropriate countermeasures at the national and international legal levels.It is noted that an important step towards preserving the environment, ensuring the safety of life and health o

read more